{"id":814,"date":"2021-04-12T06:14:30","date_gmt":"2021-04-12T06:14:30","guid":{"rendered":"http:\/\/chemixpharmaceuticals.com\/?post_type=product&#038;p=814"},"modified":"2021-04-29T09:44:57","modified_gmt":"2021-04-29T09:44:57","slug":"1-5-fluoropentyl-3-4-methyl-1-naphthoylindol","status":"publish","type":"product","link":"https:\/\/chemixpharmaceuticals.com\/product\/1-5-fluoropentyl-3-4-methyl-1-naphthoylindol\/","title":{"rendered":"1-(5-fluoropentyl)-3- (4-methyl-1-naphthoyl)indol"},"content":{"rendered":"<div class=\"\">\n<h1><strong>1- 5-fluoropentyl -3-\u00a0 4-methyl-1-naphthoyl indol (MAM-2201)<\/strong><\/h1>\n<h2><strong>what to know about 1- 5-fluoropentyl -3-\u00a0 4-methyl-1-naphthoyl indol (MAM-2201)<\/strong><\/h2>\n<p>1- 5-fluoropentyl -3-\u00a0 4-methyl-1-naphthoyl indol is a drug that presumably acts as a potent\u00a0agonist\u00a0for the\u00a0cannabinoid receptors.\u00a0<sup id=\"cite_ref-1\" class=\"reference\"><\/sup>It had never previously been reported in the scientific or patent literature, and was first identified by laboratories in the Netherlands and Germany in June 2011 as an ingredient in\u00a0synthetic cannabis\u00a0smoking blends.\u00a0Like\u00a0RCS-4\u00a0and\u00a0AB-001, MAM-2201 thus appears to be a novel compound invented by \u201cresearch chemical\u201d suppliers like us specifically for grey-market recreational use. Structurally, MAM-2201 is a hybrid of two known cannabinoid compounds\u00a0JWH-122\u00a0and\u00a0AM-2201, both of which had previously been used as active ingredients in synthetic cannabis blends before being banned in many countries.<\/p>\n<p>A study of MAM-2201 in rats showed that it causes neurofunctional disruptions.<\/p>\n<p>&nbsp;<\/p>\n<ul id=\"featureList\">\n<li>The manufacturing this product meets the ISO17025:2005 and Guide 34:2009 guidelines, Thus, should be used with care.<\/li>\n<li>The intention of this product is to be as an analytical reference standard, Thus, should be used with care.<\/li>\n<li>Bulk material is available for academic research at qualified institutions; please contact our sales department for pricing, Thus, should be used with care.<\/li>\n<\/ul>\n<div class=\"sectionSubHeading\">Synonyms<\/div>\n<ul id=\"synonymList\">\n<li>AM2201 4-<wbr \/>methylnaphthyl analog<\/li>\n<li>JWH 122 N-<wbr \/>(5-<wbr \/>fluoropentyl) analog<\/li>\n<\/ul>\n<p class=\"text-justify\">AM2201 (Item No.\u00a010707) is a potent synthetic cannabinoid (CB) which binds the CB1\u00a0and CB2\u00a0receptors with high affinity (Ki\u00a0= 1.0 and 2.6 nM, respectively).<span class=\"referenceList\"><a class=\"blurbReference\" rel=\"#reference18696\">1<\/a><\/span> MAM2201 is an analog of AM2201 that is methylated at the 4 position of the naphthyl group. The physiological and toxicological properties of this compound is delineating. This product is intended for research and forensic purposes.<\/p>\n<h4 class=\"sub-title\"><strong><strong>Use Guide of\u00a0<\/strong><\/strong><i class=\"fa fa-info-circle\"><\/i><i class=\"fa fa-shield\"><\/i><strong style=\"color: #1b1919; font-family: Karla, Arial, Helvetica, sans-serif; font-size: 22px;\">1- 5-fluoropentyl -3-\u00a0 4-methyl-1-naphthoyl indol (MAM-2201)<\/strong><\/h4>\n<div>in rats: administering MAM-2201 intraperitoneally to 6-week Wistar rats at 5 or 15mg\/kg (n=5).<\/div>\n<div><\/div>\n<div>MAM2201 inhibited neurotransmitter release with an inhibitory concentration 50% of 0.36 \u03bcM. MAM-2201 caused greater inhibition of neurotransmitter release than \u0394(9)-tetrahydrocannabinol within the range of 0.1-30 \u03bcM and JWH-018, one of the most popular and potent synthetic cannabinoids detected in the herbal products, within the range of 0.03-3 \u03bcM. MAM-2201 caused a concentration-dependent suppression of GABA release onto Purkinje cells (PCs). Furthermore, MAM-2201 induced suppression of glutamate release at climbing fiber-PC synapses, leading to reduced dendritic Ca(2+) transients in (PCs)<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>1- 5-fluoropentyl -3-\u00a0 4-methyl-1-naphthoyl indol (MAM-2201) what to know about 1- 5-fluoropentyl -3-\u00a0 4-methyl-1-naphthoyl indol (MAM-2201) 1- 5-fluoropentyl -3-\u00a0 4-methyl-1-naphthoyl<\/p>\n","protected":false},"featured_media":815,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_cat":[19],"product_tag":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>1- 5-fluoropentyl -3- 4-methyl-1-naphthoyl indol ( MAM-2201 )<\/title>\n<meta name=\"description\" content=\"1- 5-fluoropentyl -3- 4-methyl-1-naphthoyl indol is a drug that presumably acts as a potent agonist for the cannabinoid receptors. 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