Phencyclidine (PCP), known more commonly as angel dust,thu is a psychoactive drug that is, according to law, a schedule I compound in the United States.1 4-methoxy PCP is an analog of PCP which has recently been commercially produced as a designer drug.2 It preferentially binds the σ-2 receptor (Ki = 143 nM) and less weakly binds the NMDA receptor and serotonin transporter (Kis = 404 and 844 nM, respectively).3 The toxicological properties of this compound have not been reported. As such, the intention of this product is for forensic and research purposes. Phencyclidine, 1-(1-phencyclohexyl) piperidine, is a white crystalline powder which is readily soluble in water or alcohol. PCP is classified as a hallucinogen.

PCP is a “dissociative” drug; it induces distortion of sight and sound and produces feelings of detachment. PCP was developed in the 1950s to be used as an intravenous anesthetic in the United States. Thus the discontinuation of its use was due to the high incidence of patients
experiencing postoperative delirium with hallucinations. Production of PCP is no longer or used for medical purposes in the United States.

Effects of Phencyclidine

PCP’s effects include sedation, immobility, amnesia, and marked analgesia. The effects of PCP vary by the route of administration and dose. The production of intoxicating effects can be within 2 to 5 minutes after smoking and 30 to 60 minutes after swallowing. PCP intoxication may last from 4 to 8 hours; some users report experiencing subjective effects from 24 to 48 hours after using PCP. Low to moderate doses (1 to 5 mg) induce feelings of detachment from surroundings and self, numbness, slurred speech and loss of coordination accompanied by a sense
of strength and invulnerability.

Abuse of Phencyclidine

People abuse PCP is for its mind altering effects. Some can abuse it by snorting, smoking or swallowing. Smoking is the most common method of abusing PCP. Leafy material such as mint, parsley, oregano, tobacco, or marijuana contain much PCP, and subsequently, it is  in cigarettes and people smoke it. A  “dipper” is a marijuana joint or cigarette that some dips in liquid PCP. Thus, users use PCP in typically
small quantities; 5 to 10 mg is an average dose.

Physiological effects of high doses of PCP include:

• a drop in blood pressure, pulse rate, and respiration, Thus , use with moderation.
• nausea, vomiting, Thus , use with moderation.
• blurred vision, Thus , use with moderation.
• flicking up and down of the eyes, Thus , use with moderation.
• drooling, Thus , use with moderation.
• loss of balance and dizziness, Thus , use with moderation.
• violence, suicide, Thus , use with moderation.

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